The utilization of l-cystinyl-l-valine for penicillin biosynthesis
نویسندگان
چکیده
منابع مشابه
Biosynthesis of penicillins; utilization of deuterophenylacetyl-N15-dl-valine in penicillin biosynthesis.
In Paper I in this series (2) the stimulation of penicillin production by certain compounds containing the phenylacetyl group was reported. It was realized that a stimulation of yield of this biological product following addition of a given substance to the medium may result from any one of several possible metabolic mechanisms. The stimulating substance may act as a vitamin or growth promoter,...
متن کاملIncorporation of double-labeled L-cystine and DL-valine in penicillin.
l-[3,3'-(3)H]cystine was incorporated into penicillin with retention of one tritium. This result can be explained by beta-lactam formation through ring closure between C3 of cysteine and NH of valine. No radioactivity of dl-[2,3-(3)H]valine was incorporated into penicillin. The loss of isotope at C2 occurs during the inversion of configuration. The loss of label at C3 is discussed in terms of p...
متن کاملA non-planar peptide bond in L-seryl-L-valine.
The molecular structure of (I) is shown in Fig. 1. Bond lengths and angles are normal, but the unusual non-planarity of the peptide bond is quite evident. The associated torsion angle C1ÐC3ÐN2ÐC4 (!) is 157.37 (15) , a deviation from 180 that is superceded among small chiral peptides only by the 156.6 ! angle in N-(tert-butoxycarbonyl)-l-Pro-l-Leu benzyl ester (Sugino et al., 1978). Fig. 2(a) s...
متن کاملTHE CONDUCTIVITIES OF AQUEOUS SOLUTIONS OF GLYCINE, d,l-VALINE, AND l-ASPARAGINE
1. The conductivities of aqueous solutions of glycine, d,l-valine, and l-asparagine have been determined, and comparisons have been made with similar data reported in the literature. 2. On the basis of certain theoretical considerations, calculations of the expected conductivities of aqueous solutions of glycine, asparagine, aspartic acid, and glutamic acid have been made and these data have be...
متن کاملDiauxie used as a microbiological assay for L-isoleucine or L-valine in Escherichia coli.
FIG. 1. Diauxic lag of cuiltures conitaining valine and isoleucine. All cultures were grown by shakinig (330 rev/ min) at 37 C in medium containing 2.0 g ofNaH2PO4 O H20, 7.0 g ofK2HP04, 2.0 g of (NH4)2SO4, 0.2 g of MgSO4 v 7H20 and I mg of thiamine hydrochloride in I liter of distilled water. Overnight cultures grown in 0.2%o glucose were harvested by centrifugation during exponential phase, r...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1960
ISSN: 0306-3283
DOI: 10.1042/bj0760323